Don't bother with Severity or Lethality, just focus on getting rid of Total Organ Failure.
Virus: Never evolve a Symptom, the Virus will mutate them itself. Of course, each disease type will have slightly-to-heavily different strategies: Even if you think there aren't many healthy humans left, Total Organ Failure will kill the sick ones fast enough for the remaining humans to stay healthy and survive. If your disease mutated it, devolve it immediately. As a result, if you are detected, you'll want to maximize Air and Water Transmissions as soon as possible to keep infecting planes and ships despite filters.Ībsolutely do not ever evolve Total Organ Failure until after you have infected every single human. However, your disease can never cross over ship or airplane once services are shut down. Your disease can still spread to neighboring countries even when borders are locked down and animals are being killed. If you can, try and prioritize infecting islands with no infected. The only exception to that rule is Total Organ Failure (see 4.), make sure you always have enough DNA to devolve it as soon as it mutates. This does not apply to Viruses, as they mutate too quickly and cost DNA to devolve. If your disease mutates a lethal Symptom before then, devolve it. The higher your Severity, the faster the Cure Research will be, so try and keep it low even after you're detected.ĭon't increase Lethality until after you've infected every single country. 
Even a single point in Severity will eventually lead to detection (in Mega Brutal difficulty, you can still be detected with no severity), which will make it harder to infect people. Avoid increasing Severity until after you've been detected, or after you've infected every single country.
In the beginning, focus on Transmission and Abilities. This will depend on the type of disease, but in general it boils down to the following:
Until all humans are infected, keep Severity as low as possible (do not increase it, if possible), and do not increase Lethality.ĭon't evolve Total Organ Failure until all humans are infected, devolve it if necessary. Increase Infectivity as much as possible.
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